Ubiq E1

Ubiquitin E1

Ubiquitin-mediated proteolysis is an important pathway of non-lysosomal protein degradation that controls the timed destruction of a number of cellular regulatory proteins including p53. In mammalian cells, there are more than 30 different E2s and hundreds of E3s but only one essential E1. Therefore, E1 is the single common step in the ubiquitination process. While proteasome inhibitor prevents the degradative function of ubiquitination, E1 inhibitor blocks both degradative and non-degradative functions of ubiquitination and thus is a valuable tool for exploring the biological roles of ubiquitination and other components in ubiquitination pathway.

logo_forcopy offers the first generation of ubiquitin E1 inhibitor designated UBEI-41. Contact Us for more information.